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Omics-Driven Oncology: Challenges Encountered and Lessons Learned


Description:
A majority of cancers are driven by genomic alterations that dysregulate key oncogenic pathways influencing cell growth and survival.  Over the past several years, the convergence of discovery, technology, and therapeutic development has created an unparalleled opportunity to test the hypothesis that systematic knowledge of genomic information from individual tumors can improve clinical outcomes for many patients with cancer.  Routine use of sequencing to guide treatment selection is happening in various clinical and academic settings and some of the early lessons learned and challenges encountered will be described.   
 

Objectives:

1. Describe mutational profiling approaches that may enable clinicians to utilize sequencing-guided
    treatments.
2. Determine interpretive frameworks that may render complex genomic data accessible to oncology
    clinicians.
3. Discuss clinical trial designs that will optimally interrogate the utility of genomic information.
4. Describe challenges and lessons learned from implementing routine sequencing for oncology
    patients in both the newly diagnosed and advanced setting.
 
Activity Number:
0280-0000-16-080-H01-P

This recorded activity is a based on a live program that was offered on October 14, 2016 in Burlington, MA.  
Participants who received credit for the live program should not claim credit for this web based presentation.
 
System Requirements for Participants:
Operating system:  Windows XP, Vista or 7  MAC OS X  Latest Version of Adobe Reader
Browser Internet Explorer 8.0 or above  Google Chrome 16.0 or above  Firefox 7.0 or above  Safari 5.0 or above
 

Fee

$0.00

CE Hours

1.00

CE Units

0.100

Activity Type

  • Knowledge Based

Target Audience(s)

  • Pharmacists

Accreditation(s)

Accreditation Council for Pharmacy Education
American Health Resources is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education

Requirements for CE Credit

  • Complete the pre-test
  • Review the content of this activity
  • Successfully complete the post-test with a score of 80% or higher 
  • Complete the activity evaluation
Continuing pharmacy education credit is automatically reported to CPE Monitor once the post-test & evaluation is completed.
 
Pharmacists - Be sure your profile has been updated with your NAPB e-profile # and birth date information BEFORE completing the online evaluation, or your credits will NOT be reported.

Support/Credits

Disclosures:
The presenter is Casey Williams, PharmD, BCOP; Director, Avera Center for Precision Oncology; Director, Department of Molecular and Experimental Medicine; Clinical Associate Professor, University of South Dakota School of Medicine; Adjunct Clinical Associate Professor, University of Kansas School of Pharmacy; Adjunct Clinical Associate Professor, South Dakota State University School of Pharmacy
Dr. Williams does not have any relevant financial relationships with any commercial interests   
 
The reviewer is Ali McBride, PharmD, MS, BCPS, BCOP; Clinical Coordinator Hematology/Oncology, 
The University of Arizona Cancer Center, Tucson, AZ.  
Dr. McBride does not have any relevant financial relationships with any commercial interests.
 
Support for This Activity:
This activity is supported by the Association of Community Cancer Centers (ACCC)
 
American Health Resources assesses conflict of interest with its instructors, reviewers and other individuals who are in a position to control the content of CE activities. All relevant conflicts of interest that are identified are resolved by American Health Resources for fair balance and scientific objectivity.
 
Disclosure of Unlabeled Use:
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.  American Health Resources does not recommend the use of any agent outside of the labeled indications.  The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of American Health Resources.  Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

 

 

 

A majority of cancers are driven by genomic alterations that dysregulate key oncogenic pathways influencing cell growth and survival.  Over the past several years, the convergence of discovery, technology, and therapeutic development has created an unparalleled opportunity to test the hypothesis that systematic knowledge of genomic information from individual tumors can improve clinical outcomes for many patients with cancer.  Routine use of sequencing to guide treatment selection is happening in various clinical and academic settings and some of the early lessons learned and challenges encountered will be described.   
 

Objectives

  • Describe mutational profiling approaches that may enable clinicians to utilize sequencing-guided treatments.
  • Determine interpretive frameworks that may render complex genomic data accessible to oncology clinicians.
  • Discuss clinical trial designs that will optimally interrogate the utility of genomic information.
  • Describe challenges and lessons learned from implementing routine sequencing for oncology patients in both the newly diagnosed and advanced setting.

Speaker(s)/Author(s)

Casey Williams, PharmD, BCOP picture

Casey Williams, PharmD, BCOP
Director, Avera Center for Precision Oncology


Brief Bio : Dr. Casey Williams is the Director of the Avera Cancer Institute Center for Precision Oncology and the Department of Molecular and Experimental Medicine at the Avera Cancer Institute in Sioux Falls, SD. Dr. Williams received his Pharm.D. from Creighton University and subsequently completed his PGY-1 residency in Pharmacy Practice at the University of North Carolina, and his PGY-2 Oncology Practice residency at the University of Texas/Audie Murphy VA. Dr. Williams has clinical faculty appointments at the University of Kansas School of Pharmacy, South Dakota State University School of Pharmacy and the University of South Dakota School Of Medicine. His current research focus is in cancer genomics and translational therapeutics to better understand the role that specific genes have on the activity of various treatments for the treatment of cancer.

Activity Number

0280-0000-16-080-H01-P

Release Date: Nov 10, 2016
Credit Expiration Date: Nov 10, 2018

CE Hours

1.00

Fee

$0.00